Adrafinil Side Effects

Adrafinil Side Effects

Adrafinil is a compound that belongs to a eugeroic group, which means it’s a wakefulness-promoting agent. It’s broken down in the liver to produce modafinil. Adrafinil side effects are relatively mild, and are almost never felt if a normal dosage, in the range of 300 milligrams to 600mg taken consistently.

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Users can take Adrafinil when they are in need of high mental focus and alertness. They can experience the following advantages;
– Since Adrafinil is a stimulant, it increases overall energy levels, attention and prolonged physical or mental effort. People that endure night shift work and truck drivers can use this drug.
– It increases high level of productivity as a result of increased energy and motivation. Individuals who are working in competitive fields such as industries can benefit from this drug greatly.
– Adrafinil also increases learning ability and boosts the memory, but based on one’s cognitive ability. Faster recall is experienced in terms of remembering information. It is useful during exams period as one is required to produce information at a faster speed.
– It enhances motivation and task enjoyment when working.
– It also makes mental work less exhausting by curbing some of the strain one may feel when working for long periods of time. People who suffer from mood disorders like stress, anxiety, and depression during the day may use Adrafinil.

– Improves problem-solving abilities and general cognition when making a sound decision. It keeps the mind alert at all times.

 Adrafinil Side effects Long-Term

Adrafinil has some side effects and users should be advised about them so that they may be able to make a decision whether to use them or not. These are as follows;
– Taking a large dosage can result in a headache, dizziness, nausea, dry mouth, irritability, hallucination, chest pain, heart palpitations, and stomach discomfort.
– It can lead to liver toxicity because the drug is broken down and converted to Modafinil in the liver. It makes the liver release some enzymes that can potentially become harmful over an extended period.
– Heart complications may also be experienced especially by users who take other stimulants along side with Adrafinil, this is possible due to a strain on the heart in blood circulation.
– Insomnia can also be a problem. Those who take Adrafinil late at night will find it impossible to fall asleep during the normal hours. It is because it causes mental alertness, hence reducing fatigue and produces a natural sense of being alert. Also, the sleep cycle will be altered.


Adrafinil is thought to imitate the chemical process by which the body is prepared to fight and flight in response to the presence of an emergency when it occurs. This compound increases the level of the neurotransmitter hypocretin in the body.

It also causes an increase production of hormones such as neurotransmitter like Dopamine, Norepinephrine, and Histamine. Adrafinil drug is associated with both mental, and physical energy level and play a major role in the wakefulness and alertness.

Adrafinil is used to prevent the breakdown of Dopamine, which helps to improve mood and reduce stress. Furthermore, it’s used to stimulate the release of Serotonin that can help to regulate sleep as well as anxiety, night workers can benefit from this.

Again, Adrafinil modulates glutamate receptors that are believed to be the mechanism of action for the cognitive benefits. It may also be used to improve memory, better brain, and neuronal communication, and enhances cognitive performance.

User reviews of Adrafinil Side Effects

Many nootropic users prefer Adrafinil over Modafinil. These two drugs are metabolized differently, with Adrafinil being converted into modafinil in the liver. Adrafinil is not restricted in the USA, and it’s cheap while Modafinil is a controlled substance. Adrafinil users had suggested that this drug gives it immediate results after taking in an hour of orally ingesting; only 300mg capsule is enough to cause the reaction.
Adrafinil can make one become alert and energized, it decreases errors in the performance of a task. Most students prefer Adrafinil drug because it improves mental performance and keeps intelligence strong. It also challenges the mind to its mental breaking point for effective results. One should use it before time to make the mind mentally prepared, and it also should not be taken daily.

Dosages to Avoid Adrafinil Side Effects

It’s very important to users of Adrafinil to know the proper dosage of the drug to avoid some side effects when the recommended dosage is exceeded. It’s therefore recommended that users the Adrafinil drug should be taken in an amount that does not exceed 300mg per day for adults. This compound is water soluble and that it can be either taken in capsule format or by mixing it into a drink.

The best technique is that one should begin with a low dose and increase after seeing how the body is reacting to it. This process should be done two weeks after the effects have been felt; this is done to allow the body to have enough time to build up a tolerance.

The users should make sure that the dosage is taken two or three times each day, without taking another dose beyond the noon time hour; this is to avoid insomnia in some folds. Adrafinil won’t necessarily have benefits when taken in a large dose exceeding 300mg. The lower the dosage, the lesser your chances are of experiencing its negative side effects.

Long-term effects

The most common side effects of Adrafinil drug are the liver problem. There could be some liver toxicity due to breakdown and conversion of Adrafinil drug into Modafinil. Users who consume alcohol, and at the same time take Adrafinil, should not be doing so as they overwork their liver.

Also, skin condition had been reported to have emerged due to the use of this drug, Steven-Johnson Syndrome, Dress Syndrome, and Toxic Epidermal Necrolysis are the major complaints.

Short-term effects

It may cause one to become nervous since it affects the nervous system. It occurs when hypothalamus increases the level of histamine that plays an important role in regulating the sleep –wake cycle.
When used for a short period, it can cause nausea, headache, and loss of appetite, weight loss, and dizziness.

Is Adrafinil legal?

Adrafinil is a powerful nootropic agent that provides users with a sense of alertness and awareness. Countries such as USA, UK, and Canada Adrafinil are legal, but some countries require a prescription that allows patients to import small quantities for personal use.
The World Anti-Doping Agency has added Adrafinil to its list of prohibited drugs for athletics competition. Therefore, it is recommended for one to know whether Adrafinil is prohibited or not in each country one admires to visit.

Adrafinil Liver Toxicity

The liver metabolizes Adrafinil into Modafinil through the action of detoxification. This drug increases the release of liver enzymes that are used to break down toxic substances into less harmful substances. It can lead to problems and eventually toxicity within the liver. When these substances accumulate in the liver due to long-term usage of Adrafinil drug, they can cause irreversible damage to the liver. Moreover, the strain that causes further stresses the liver of the user, this is common especially users who already has liver issues especially those with hepatic problems.

Supplementing with milk thistle will prevent the liver damage from prolonged Adrafinil intake. It helps in detoxifying the liver. Milk thistle if recommended that is should be taken after cycling with Adrafinil or when the user takes a break from Adrafinil use.

Adrafinil vs Modafinil Side Effects

Both Adrafinil and Modafinil were developed for similar purposes that promote wakefulness and alertness. They all work in a similar way, but modafinil has fast effects and lasts longer than Adrafinil. The major difference between these two drugs is that the nature of the side effects and the rate at which these drugs become active in the body is different.

Modafinil is not available over the counter, and it requires a prescription from a doctor. It requires a lower dose than Adrafinil, and it doesn’t need be metabolized by the liver, this makes it be a better option for long-term supplementation. Long-term use of Modafinil can result in heart damage due to a drastic increase in blood pressure.

In some countries of the West, for example, United States of America and Canada, Adrafinil is unregulated. This drug can be imported privately by citizens or be purchased as a research chemical. It’s legal, and it can be therefore be used as Modafinil alternative.

Adrafinil History

Adrafinil was first discovered in France by a pharmaceutical company “Lafon” in the late 1970s. The Lafon Company also developed Modafinil, the primary metabolite of Adrafinil. The drugs were considered to be a central nervous system stimulant just like other stimulants such as coffee, energy drinks, and soft drinks.
This drug was first sold in France as a treatment for sleep disorders that makepeople alert almost all the time. The drug helps to alleviate the symptoms of sleep disorder making the patient live a normal life.

Adrafinil Research

Adrafinil is said to peak in the blood of elderly humans approximately one hour after oral ingestion. Neurological effects occur immediately after this peak since this is the time it takes to be converted into modafinil, which is its active metabolite. Adrafinil can also be converted directly to modafinilic acid without producing modafinil.

Final thoughts on the Main Adrafinil Side Effects

Adrafinil can be seen as a safe and effective supplement that can be used without a prescription from physicians in most countries such as USA, Canada, Australia, Mexico and in the United Kingdom. This drug should be used properly as prescribed by the physician to avoid its possible side effects. New users should use it at a dose as low as 100 to 150 mg per day and only work up from there as need. Those ones who had been using should not exceed a dose of 300mg per day not unless with the advice of a physician.

All users should, therefore, keep in their mind the risk of exposing their bodies to the risk of liver disease when they frequently use it under a high dose. Users should consider using an on-off type of cycle to prevent tolerance and the build-up of unhealthy enzymes in their bodies.

By following the recommendations and requirements, users should be able to use this supplement in a healthy manner that can lead to some incredible benefits in their future life.

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