Adrafinil vs Modafinil

Adrafinil vs Modafinil

Adrafinil
This is a chemical agent that promotes wakefulness, and is used to relieve excessive sleepiness and loss of attention.

History

Adrafinil was discovered in the late 70s by some scientists working Group Lafon; a French pharmaceutical company. It was first offered in 1986 as a tentative treatment for narcolepsy but then the company developed the drug called Modafinil, which is the primary metabolite of adrafinil.

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More Information

It does not presently have any FDA approval and is therefore, in the US. It went on sale under the Olmifon elsewhere in Europe, except in France until 2011 when its FDA equivalent reassessed the drug and withdrew marketing permission. The reason for this was known adverse reactions and unpleasant risk to benefit ration. When comparing Adrafinil vs Modafinil, their effects, benefits and dosages, keep in mind that while Modafinil is stronger, Adrafinil is a better drug for long-term use!

Mechanism of action, Adrafinil vs Modafinil

The exact mechanism of action for this drug is unclear. However, most researchers suppose that both adrafinil and Modafinil serve as adrenergic receptor agonists.  There exists weak evidence in support of this and other mechanisms are probable.

It is a prodrug that is primarily metabolized similar to Modafinil thus resulting in identical pharmacological effects. In comparison to Modafinil, this drug takes time for the metabolite to accumulate to active levels in the bloodstream. When taken orally on an empty stomach, the effects are seen within 40-60 minutes.

Who uses the chemical?

The product can be used off-label by individuals who are looking forward to avoiding fatigue, especially night workers or others who need to stay awake and alert for longer periods of time. University students who have many random papers can use this chemical to stay awake without feeling fatigued and less on energy. The effects will be evident after the 45-60 minutes. This effect will stay for a longer period of time, allowing them to do proper revision and sitting of the same exams without any complaints of fatigue at all.

Good Effects of the chemical

After taking the drug, there are effects that will accompany the consumption. Some of the effects include:

  1. More attentiveness. Problem of lack of attention is no longer there for someone who has taken these drugs. You will be able to stay alert and focused. Consider it the best drug alongside Modafinil
  2. Reduced excessive sleep. For people who are suffering from sleeping long hours due to either working at night shifts or just naturally, taking this drug reverses it.

 

Side effects of the drugs, Adrafinil vs Modafinil, Which has worse Downsides?

There are some side effects of using this drug for anyone willing to enjoy the benefits accompanying it. The side effects are;

  • Stomach pain. People who used this drug complained of stomach pains after a while. But not so serious.
  • Skin irritation. Since the brain works with neurotransmitters, the skin as a receptor feels irritations at some point.
  • Anxiety and (with prolonged use) elevated liver enzymes. When the nerves are stimulated in the process of curing excessive sleep, the feeling of anxiety comes along.

Any drug being used to administer certain issues, has some good and side effects. However, the drug adrafinil offers you the effectiveness with minimal side effects. Overall, because it is stronger, Modafinil has worse side effects than Adrafinil.

Dosages

Dosages of Adrafinil range from 3-1200 milligrams per day. This is because Adrafinil is a pro-drug, meaning it converts to Modafinil in the liver, making the drug somewhat weaker than genuine Provigil. Provigil dosages range from 1-400 milligrams daily, with an absolute maximum dosage at 400 milligrams, anything higher than this and the effects start to go downhill. Provigil is around 1-2 times stronger than Adrafinil. However, as you’ve seen advertised on the site, Hydrafinil, is around 4x stronger than Provigil. Way cheaper too, dosages of this are from 50-80 milligrams in a serving.

Side Effects

The side effects of Adrafinil are somewhat milder than Modafinil, because it is weaker. In the fight of Adrafinil vs Modafinil however, both side effects, though they may vary in terms of potency, are the same as far as what effects occur. These are:

-Headache

-Dehydration

-Loss of appetite

-Jitters

-Euphoria

-Insomnia

You may or may not experience any or all of these side effects. This is not a complete list either. For a general idea of what side effects will feel like on the user, observe how you feel when you drink coffee or a caffeine-containing product. Adrafinil/Modafinil will have much the same side effects on the user.

What will I feel

You’ll feel a jolt of calm, productive energy, and will have a slight euphoria. Focus, mood, energy levels and memory will be increased significantly.

Research in Mice

Clinical trials in mice and rats have shown Adrafinil to be effective. Adrafinil does not build tolerance rapidly like most other stimulant medications.

Sources: 

  1. http://www.ncbi.nlm.nih.gov/pubmed/3713198

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