Where To Buy Sam-E Supplements Online: The Best Places & The Best Brands


Perhaps you’ve heard of SAM-e supplements before. The name SAM-e is short for S-adenosylmethionine, an intermediary in the transformation of amino acid L-methionine into homocysteine. SAM-e is requisite for multiple bodily functions, production of Dopamine and Serotonin chief among them.

SAM-e supplements are popular among “natural warriors” for their ability to alleviate pain and lift mood. They are also useful for protecting your immune system and promoting joint health.

Although SAM-e was initially discovered in the Fifties, SAM-e supplements have only been on the market since the late-Nineties. Its effects on depression, liver disease and more have been the topic of much debate and several studies.

Those looking to obtain SAM-e supplements for joint pain, depression and a myriad of other conditions can seek it out online and, in some instances, in their neighborhood retail outlets. This, of course, is dependent upon its availability in your area.


As stated above, SAM-e can be beneficial to those afflicted with any number of health conditions. SAM-e uses are manifold and many people have been taking them for daily use. You may use it to treat anxiety, depression or as a nootropic alternative to traditional mood-enhancement drugs.

SAM-e has been implemented in cases of migraines, chronic lower back pain, fibromyalgia, osteoarthritis, PMS (Premenstrual Syndrome) and bursitis. It is also used as part of a medical regimen to help those afflicted with liver disease, heart disease and MS (multiple sclerosis). SAM-e is known to support stronger cartilage and can be advantageous to those who have CFS (Chronic Fatigue Syndrome) and other immunological conditions. It has also been helpful to people with ADHD (Attention Deficit Hyperactivity Disorder).

While much has been written about SAM-e supplements and several trials conducted to support the above claims, additional studies must be undertaken in order to confirm its effectiveness in these areas. For this reason, the FDA (Food & Drug Administration) has not approved SAM-e as a medication.


SAM-e is readily available to those consumers who shop online. It is ready for purchase on Amazon and at vitamin vendors like GNC and Puritan.com. There are several brands out there, the likes of which include Source Naturals, Jarrow Formulas, Doctor’s Best, Now Foods and many more. The most popular on Amazon appears to be Doctor’s Best’s which comes in either liquid form or a 400 mg enteric-coated tablet.


Recommended dosages for SAM-e tend to fall somewhere between 200 and 1,500 mg. 400 mg is generally considered to be standard serving, although many take much more. Sundry factors determine what the right dose will be for you. These include age and health condition. Users should consult with their primary care provider to establish what dose is right for them.

There are two forms of SAM-e—RS and SS. Users should seek out the SS form as the RS form is inactive and is unlikely to have any efficacy whatsoever.

Users often stack SAM-e supplements with glucosamine and similar products to support optimal joint health. As always, users should consult with their doctor prior to stacking supplements.


Like most medications and dietary supplements on the market, SAM-e may have some adverse effects. Taken in moderate doses, these may include any of the following:

  • Anxiety
  • Dizziness
  • Headaches
  • Dry Mouth
  • Nausea
  • Diarrhea

In extreme cases, SAM-e has been shown to cause heart palpitations and insomnia. For this reason, SAM-e should not be administered before bed or in the late hours of the day.

If you suffer from bipolar disorder, DO NOT TAKE SAM-e supplements as they have the potential to cause acute manic episodes. Be safe, be smart and emancipate your mind.

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