How to Increase Acetylcholine Levels

What Is Acetylcholine?

Acetylcholine is a powerful neurotransmitter that regulates a host of function in the human body and mind. A lack of acetylcholine is usually inducing of symptoms like a bad memory, sadness, tiredness, a lack of focus, and brain fog. By using certain supplements that can increase Acetylcholine, you can not only prevent this, but also gain enhancements in memory, mood, focus, and clarity of thought, among other functional benefits. Aside from supplements, diet can also play a major role in one’s level of the neurotransmitter Acetylcholine in the brain. A host of supplements like Piracetam, Aniracetam, and Pramiracetam have been shown to affect this neurotransmitter. Most of these supplements do not require a doctors prescription to get.

Acetylcholine Benefits and Importance

Acetylcholine is important because of its effects in maintaining a baseline state, as well a supporting healthy memory and mood.

Supplements for Increasing Acetylcholine Levels

A host of supplements, natural or otherwise, have been shown to have significant benefits on the acetylcholine receptors in the brain. Some of these are

  1. Piracetam – A racetam nootropic supplement that uses your brain natural choline stores to create and boost levels of Acetylcholine. It is often deemed the “original nootropic drug” because of how old and subtle it is. Very noticeable effects if taken on a regular basis.
  2. Aniracetam – Very similar to Piracetam, except 5-10 times the strength and with an added calming effect.
  3. Eggs – Chalked full of protein and omega 3’s, these work in conjunction to boost Acetylcholine levels in the brain.
  4. Meat – Protein-acetylcholine
  5. Dairy – Same deal
  6. Brussel Sprouts – A veggie packed with raw vitamins and minerals, because of such a vast supply of nutrients, its no wonder that it can help boost Acetylcholine levels in the brain naturally (though far less than most of our supplements.)
  7. Broccoli – Many of the same nutrients as brussel sprouts, ergo many of the same effects with regards to boosting the neurotransmitter Acetylcholine in the brain.
  8. Alpha GPC Choline – Ah the most powerful choline supplement on the market (even though fish oil and omega 3’s are the most popular.) Alpha GPC Choline has a whole host of brain benefits that derive from the way it can increase the brains Acetylcholine stores, these include, better memory, mood, and focus.

Main Nootropics for Increasing Acetylcholine Levels

  1. Piracetam – Piracetam is often called “the original nootropic drug” and for good reason. Piracetam was first synthesized in the 1960s, and as such has nearly 70 years of research to back it. Piracetam is very effective, yet also very subtle.
  2. Noopept – Noopept is one of the most powerful nootropic supplements for increasing acetylcholine levels, if not the most powerful. Noopept has been touted to be as much as 1000 times as strong as the leading base nootropic drug, Piracetam. Not sure if I mentioned this by the way but choline supplements, whether CDP Choline or Alpha GPC Choline, is an absolute MUST when taking racetams and other acetylcholine increasing nootropics. Anyhow, Noopept is the bee’s knees with regards to Acetylcholine supplements, if you’re looking for a serious boost, give it a ride. Just be sure to take it with choline, otherwise, you may get a mild headache and become tired and cranky.
  3. Aniracetam – Five times the strength of Piracetam, with added relaxation qualities.
  4. Oxiracetam 15x the strength of Piracetam, with an addy speedy effect.
  5. Pramiracetam – 30 times the strength of Piracetam, no added super effects, just a super strong Acetylcholine supplement.
  6. Phenylpiracetam – Phenylpiracetam is 40 times stronger than the base nootropic drug Piracetam. It is actually Piracetam with an added Phenyl ring (hence Phenyl-piracetam. “Phenyl” short for Phenylalanine, the amino acid that creates dopamine. Therefore Phenylpiracetam is very effective at jacking up dopamine levels, as well as Acetylcholine.) If you’re reading this article and are looking to increase acetylcholine levels, increasing dopamine will have much the same effects.

Exercise: An Alternative for Increasing Acetylcholine Levels Without Supplements

You can increase Acetylcholine levels naturally via exercise, eating plenty of protein and a load of collard greens. While not as effective as many of the supplements we offer, such as Piracetam, Sunifiram, and Noopept, this is, in fact, a natural way to over-time improve overall levels of Acetylcholine, as well as spark a cocktail of increased neurotransmitters that will improve to much the same effect, including dopamine, norepinephrine, serotonin and endorphins.

Dosages of Our Top Supplements to Increase Acetylcholine

  1. Piracetam Dosage – Typical dosage of Piracetam is 8-2400 milligrams daily.
  2. Noopept Dosage – Typical amount of Noopept is 10 to 20 milligrams 1 to 2 times daily.
  3. Aniracetam Dosage – A typical Aniracetam dosage will look like 7-1400 milligrams per day.
  4. Oxiracetam Dosage – 8-2400 milligrams daily.
  5. Pramiracetam Dosage – 250-1000 milligrams daily.
  6. Phenylpiracetam Dosage – 100-300 milligrams per day. Always be sure to take loads of choline whilst using any of these powerful Acetylcholine supplements. Or more specifically, Acetylcholine reuptake inhibitors.

Safety Concerns

Most of these are absolutely safe to take for long-term use. Piracetam, Aniracetam, and Oxiracetam are best for long-term use. With regards to some of the stronger ones such as Phenylpiracetam and Noopept, regular use is not advised. If you want to know how to increase Acetylcholine on a very regular basis, however, subtle nootropics such as Piracetam and Alpha GPC Choline are great ways to do just that!

The best long-term ways to increase Acetylcholine are via supplements (safe and subtle ones, such as Piracetam and choline) and to improve diet, adding in loads of protein, omega-3 fish oil’s, and leafy greens. Exercise is also a great way to improve Acetylcholine levels! Acetylcholine levels have also been known to decrease somewhat in times of extreme stress and anxiety, so try and keep these at bay. Something like meditation can work wonders for increasing this.

Megadosing Acetylcholine Products

Megadosing Acetylcholine products, such as Piracetam and Aniracetam, is very strongly not recommended. what this refers to is taking a dose that is from 10 to 30 times the recommended amount, in order to increase its effectiveness. While this would work, it also comes with a debilitating crash, so please don’t do this. You can read reviews about the extreme highs and lows of this right here

Fish Oil for Natural Acetylcholine Improvement

Fish Oil is a very powerful and common form of Acetylcholine in the brain. So be sure to stock up on your Omega 3’s if you’re looking for how to increase Acetylcholine in the human brain.

The Magic of Omega 3’s

Again, fish oil is awesome for increasing Acetylcholine, as a natural method. I’d recommend skipping the fish oil for some CDP Choline as it’s much stronger. Adding actual fish to your diets, such as salmon or tilapia, can be a great way to increase Acetylcholine whilst swapping out the fish oil for something like Alpha GPC Choline, CDP Choline, DMAE or Centrophenoxine.

Final Thoughts on How to Increase Acetylcholine

The best ways are through natural supplements, such as multivitamins and fish oil, or through powerful synthetic nootropics, such as Piracetam and Noopept. Diet, and exercise, including fish, protein-packed meats and eggs, dairy and green vegetables are also packed with Acetylcholine boosting nutrients, so be sure to stock up!


  1. Ronan
    , 2016-10-23

    Nice post! Never considered exercise before as a natural way to boost acetylcholine. One of the best nootropics for me is Neuro-Peak. I like it because it just does what it says it does– no BS. It simply boosts your focus, and unlike many products on Amazon. It works. I found a pretty helpful review of it over at Brin Hack Reviews if anyone is interested in reading more:

    I’ll definitely utilize your suggestions here. Well-written and well-thought out article. Thanks.


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