Guidelines For The Proper Usage Of Noopept

What Is Noopept?

Thought to be one of the strongest and most effective nootropics (a class of supplements designed to boost memory and improve concentration) on the market, Noopept is most often taken by people who are hoping to increase their brainpower and enhance their cognitive abilities. Noopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester. Originally developed in Russia, Noopept is most often used in Europe. However, it was made available in the United States in 1995 due to the significant demand from people who believe that could benefit from Noopept.


Developed by a Russian pharmaceutical company, JSC LEKKO, in the 1970s, Noopept is currently available by prescription in Russia, while the European Medicines Agency and the U.S. Food and Drug Administration (FDA) have yet to approve or disprove its use. It is important to know that the possession of any nootropic in the United States is completely legal for the purposes of “education and research”.


Noopept is often compared to two other nootropics, Piracetam and Aniracetam. However, Noopept is 1,000 times more potent due to how it is absorbed and metabolized, according to the manufacturer. Additionally, it is said to be 5,000 times more potent than Aniracetam. As a result, Noopept is taken in substantially smaller doses than the other two nootropics, while still offering enhanced benefits.

Noopept has been proven to have numerous benefits including:

  • Improved short and long term memory, which shortens how long it takes to recall both new and old concepts.
  • Enhanced clarity, logical reasoning skills, learning ability, attention span, and overall cognitive performance.
  • Heightened reflexes and sense of perception. For example, it is not unusual to notice that colors are more vivid or your hearing is enhanced.
  • Improved mood, as well as decreased levels of stress, anxiety, and depression, which leaves users feeling calmer and more content.
  • Improved mental energy and ability to focus.
  • Enhanced verbal communication skills.
  • In some cases, it helps improve motivation and drive. Some users even report they feel that it gives their self-esteem a boost.

Recommended Dosages

Per the manufacturer’s recommendations, anyone taking Noopept in powder form should take 10 mg a day, using the included scoop. You can mix it into a drink to try and mask the flavor. Some people may choose to hold it under their tongue for up to 10 minutes before swallowing because this is generally considered to be a more effective supplementation method. A safe amount to determine Noopept’s effect on you is 10 mg when first starting out.

The manufacturer recommends that individuals who prefer capsules should start with one 10 mg capsule a day. However, if this does not have the desired effect, you can take up to 40 mg three times a day. Most research directs that Noopept is safe even at high doses.

Side Effects

When taken as suggested, Noopept has a very minimal risk of side effects, especially when compared to other nootropics. However, the most commonly reported side effect is headaches, which will be discussed more in-depth below. It also may cause irritability in a small number of users and in some cases, it has been reported to increase blood pressure. If you have a history of or at high risk for developing high blood pressure, it is a good idea to monitor your blood pressure for any changes.

When Noopept is taken at higher doses, it can result in gastrointestinal problems, such as a stomachache or diarrhea. This also increases the risk of insomnia and headache. These side effects can be relieved by lowering the dosage.

How Long Does This Last?

Although Noopept has a half-life of 30 to 60 minutes, most users do report they continue to feel its effects for as long as 3 to 4 hours are taking it. As a result of the short half-life, many people find it most effective to take it in 10 mg increments every 3 to 4 hours during the day to get the maximum benefits.

Are Noopept Headaches A Potential Safety Concern?

The glutamate, an excitatory neurotransmitter that Noopept works so hard to keep from breaking down in the brain is also responsible for migraine headaches. This is one of the primary reasons that headaches are the most commonly experienced side effect of Noopept. In addition, Noopept enhances the use of acetylcholine in the brain. Low acetylcholine levels are also notorious for causing headaches.

Why Does This Require Choline?

The easiest and most effective way to eliminate caused by Noopept is to eat foods high in choline, a nutrient that is similar to the B vitamins. These foods include eggs, pan-fried beef liver, and toasted wheat germ. If you aren’t a big fan of these foods, you also have the option of taking a choline substitute, such as Choline Citrate or Choline Bitartrate. Choline adds to the safety of Noopept, in that it ensures the user has an adequate supply of the important amino acid.

Does Noopept Cause Withdrawal Symptoms?

Although Noopept does not technically result in withdrawal symptoms, you will stop experiencing the short-term benefits of the supplement when you stop taking it. In some cases, it may take a couple of days to resume feeling “normal” again. Essentially, you will not experience any physical symptoms of withdrawal, but it takes a few days to begin feeling like your old self again.

There is also no reason to worry about building a tolerance or developing a physical addiction to Noopept. Historically, nootropics have not been shown to result in any type of addiction or tolerance, unlike many other substances on the market that claim to have similar benefits.


Several studies have been performed on Noopept to determine its effectiveness and what exactly it can potentially do. The following looks at some of the most significant results found in various scientific studies.

  • In a 2008 study, researchers determined that Noopept stimulated the expression of BDNF and NGF in the hippocampus of a rat [1].
  • Studies performed on animals in 2011 found that Noopept increases alpha/ beta1 (neurons that communicate with each other in the brain) activity throughout the brain [2].
  • A separate study conducted in 2014 found that Noopept could potentially aid in the treatment of Alzheimer’s disease [3]. Noopept was shown to reduce symptoms and possibly even repair some areas that had already been damaged. As of now, it is not a cure because it only thwarts specific symptoms.
  • Animal studies have found Noopept enhances memory and is neuroprotective, as well as easily penetrates the blood-brain barrier in rats [4].

How Does Noopept Work In The Brain?

First, it’s important to note that Noopept has a high oral bioavailability rate and as much as 90 percent of it makes it into circulation to the brain, which is why it is so much more potent than other nootropics. After Noopept has entered the brain, it quickly crosses the blood-brain barrier in order to bond with glutamate receptor sites and prevent the breakdown of glutamate. This is crucial because glutamate is involved in numerous brain functions, including memory, learning, and cognition. It also stimulates serotonin production, which is responsible for its mood-boosting benefits, as well as the use of Acetylcholine, a neurotransmitter that plays an important role in learning, in the brain. Many users ask “Is Noopept safe in the brain?” The answer is yes! Noopept has decades of research behind it and allows its users’ acetylcholine receptors to move to more critical parts of the brain, such as the frontal lobe.

Noopept has also demonstrated an ability to increase the levels of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF). BDNF plays a role in the specialization of new synapses and neurons in the brain. New synapses are believed to be important in overall intelligence and cognitive health, as well as long term memory, while neurons work collectively to form our thoughts. There is also evidence that BDNF may assist in the formation of new connections in the brain, which enhance communication between the two hemispheres of the brain. NGF is responsible for the growth and survival of specific neurons in the brain.

Due to the effect, Noopept has on neurons in the brain, they are able to enhance neuroplasticity. This is important because as we age, many of the neuron connections in the brain begin to die off without being replaced, which results in lost memories. However, enhanced neuroplasticity prevents this from occurring, making it easier to retrieve memories, even those that may be stored deep within the brain.

Final Thoughts

Overall, Noopept appears to be a highly effective supplement for anyone who struggles with memory, concentration, focus, and other cognitive abilities. With little to no side effects, with the exception of headaches, which can be controlled, it is safe. As an added bonus, it is cost effective, doesn’t require that users take frequent large doses, doesn’t present a risk of addiction, and is readily available. When you look at all Noopept has to offer users, it is easy to see why it is becoming an increasingly popular study aid among college students.

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