Noopept Stacks 101 – A Beginner User’s Guide

What Is A Noopept Stack?

Noopept is a dipeptide nootropic closely related to the racetam family. This nootropic supplement is famously quoted as being 1000 times stronger than Piracetam. For this reason, a much smaller dosage is needed to get effects compared to its family member (20 mg as compared to 850 mg).

In Russia, Noopept is prescribed as a nootropic medicine. It is sold under the brand name: GSV-111. The nootropic was created by JSC LEKKO Pharmaceuticals and currently holds a USA patent. Noopept has not yet been approved by the FDA; however, it is legal to obtain and easy to get online from popular nootropics vendors.
Noopept has a long-term safety record as a medicine and nootropic supplement. It is older than Piracetam, however, thousands of nootropic fans use it every day to help enhance their cognitive functioning. The cost per dose of Noopept is the lowest it has ever been and perhaps one of the most affordable nootropics on the market in 2016. For this reason, the brain enhancer is popular amongst college students looking to get an extra boost.

How The Noopept Stack Works

Noopept works primarily by modulating the acetylcholine neurotransmitter. Acetylcholine makes up only a small portion of the active chemicals in the brain (1.8%) however, it has a host of important functions. The brain chemical is vastly important for the nerve to muscle communication. It is also extremely important in cognitive tasks such as learning, memory & sensory perception. Improving the function of acetylcholine is the primary nootropic effect of Noopept.

Noopept is known as a positive allosteric modulator of acetylcholine receptors. It does not directly increase acetylcholine but instead, increases the signal of acetylcholine, therefore, increasing the positive effects. This is believed to be the primary mechanism of this nootropic.

A secondary mechanism is observed with Noopept. It appears to have some effects on AMPA and NMDA glutamate receptors similarly to some racetam nootropics. Glutamate receptor activation is also important in learning and memory. It is not quite understood how much Noopept’s nootropic effects are a result of Glutamate receptor activation. This nootropic does not need to be prescribed by a doctor. A Noopept stack typically includes CDP Choline.


The benefits of Noopept can be seen to be consistent with other racetam nootropics. Many have reported modest to mild increases in cognitive processing including but not limited to:

  • Increases in verbal & spatial memory
  • Higher cognitive processing
  • Sensory perception improvements
  • Better reflexes
  • More fluent speech patterns
  • Improved mood

For these main reasons, fans of Noopept certainly love the nootropic. It is not believed to be addictive like Adderall and other stimulant cognitive enhancers. Noopept is easy to obtain and at a cheap price that is affordable for all. On top of this, it is non-psychoactive but can improve mood without causing much tolerance or addiction. Noopept’s improvements in mood may be a result of direct or indirect activation of Serotonin receptors. Noopept stack prescriptions will typically include Piracetam or CDP Choline.

Side Effects

Even though Noopept is considered safe and relatively non-toxic, it can still produce mild side effects. Reports of side effects in users are less than 10% and usually considered very benign in severity. No serious or moderate drug interactions have been reported with Noopept to date but one should always consult a doctor before use.

The most common side effects reported with Noopept are mostly headaches and brain fog. It is unclear why some users experience these symptoms but several experts have suggested it is due to the modulation of cholinergic activity and the direct interaction between dopamine and serotonin neurotransmitters. For headaches, it has been suggested that lowering the dosage or adding in a choline source like Alpha GPC may help eliminate these symptoms.

Final Thoughts On Noopept Stacks

Noopept is a very “stackable” nootropic meaning, it can combine well with other nootropics in order to create a synergistic effect. Since this nootropic is very cholinergic, naturally a choline source comes to mind. Not all “choline sources” are created equal and it has been suggested that Noopept goes best with Alpha GPC although, Citicoline (CDP Choline) may be another great option.

Most people do not stack Noopept with Piracetam, Aniracetam or Oxiracetam, however, Phenylpiracetam is a popular choice and has been suggested by users to offer really great effects. This is a really popular stack that many people are using in 2016.

All in all, Noopept is great by itself or stacked with other nootropics. If you are looking for a powerful nootropic, suited for beginners and user on a budget, it is highly recommended to try Noopept!

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