What Is Sunifiram?
Nootropics are the latest innovation in supplements that offer the chance at brain-enhancing capabilities. These new “smart drugs” offer the opportunity to improve memory, cognitive functions, and even ease the symptoms of oncoming Alzheimer’s disease. The most popular examples like Piracetam and Nooept have shown to be worthy of these claims. Now, a new nootropic is starting to generate buzz among those who have been keeping track of the rise of these smart drugs. Said to be 1000 times more potent than Piracetam, Sunifiram is the latest nootropic to show promising results in it’s release to the public. Purporting to improve memory function as well as attention span, learning, decision making, and alertness, there are many reports and reviews of Sunifiram’s effect that back up these claims. The average Sunifiram half-life is normally 30-45 minutes.
Sunifiram is a nootropic similar to Piracetam but way stronger. It’s a 1-benzoyl-4-propanoyl piperazine agonist that is supposed to enhance memory and is being studied as a way to treat Alzheimer’s or other illness that cause cognitive decline. Sunifiram supposedly makes information recall much easier, enabling clearer thinking. Many compare it to a similar nootropic called Noopept because of their similar levels of potency, though further studies have suggested that Sunifiram is better at memory boosting while Noopept has an edge on increasing alertness and focus.
Because of the relative newness of this supplement, it doesn’t have much history to report. Developed in 2000, it has only recently become available to the public in the last couple of years.
Sunifiram stimulates many of the same AMPA receptors in the brain that other racetams do but in different ways. In clinical trials, the tested patients were given an AMPA antagonist called NBQX and then Sunifiram. The test subjects saw increased AMPA receptor activity (AMPA receptors are said to be responsible for how much glutamate – an important neurotransmitter that’s responsible for communicating excitatory transmissions, forms connections between synapses, and regulates brain cell survival – is produced in the brain). With regards to the drug’s short half-life, Sunifiram gets out of your system quickly, which is good with regards to side effects, headaches, and allowing the drug to wear off faster.
Those with not enough glutamate present in the brain see their cognitive abilities greatly impaired, which results in less attention span, poor ability to learn information and a bad memory. Sunifiram has been shown to raise levels of glutamate so brain performance is increased. Test subjects found that Sunifiram makes it easier to remember information and learn new concepts.
Studies have also shown that taking Sunifiram is Cholinergic. This means that it causes more of the neurotransmitter Acetylcholine to be released. Increased levels of Acetylcholine in the cerebral cortex can lead to improved thinking, perception, alertness, learning, memory, and focus. This neurotransmitter also makes it easier for your left and right brain hemispheres to communicate and help you to recognize patterns and connections more effectively. It even can improve basic social skills like talking in group settings.
Compared to other nootropics, Sunifiram is much more potent and requires smaller dosages. It’s even considered stronger than Noopept, so new users should not assume that these two nootropics work at the same dose level just because both have been referred to being “1,000 stronger than Piracetam”. The recommended dosing of Sunifiram is between 4 mg to 8 mg taken a maximum of three times per day, working best when placed it under your tongue. Typically the more of the supplement you take, the longer the drug’s half-life (though usually not by a significant amount.)
Some take as much as 10 mg at a time to produce greater stimulation similar to what many experiences when using Adderall. However, this quantity may increase the risk of side effects and it may cause tolerances to build up faster than normal. Users suggest cycling Sunifiram dosages to avoid forming a tolerance to the drug’s effects. New users should start with a half dosage so they can first observe how this Ampakine affects them.
When taking a compound this strong, attack doses or a mega dose for increased effectiveness are strongly discouraged. Taking too large of a dose may result in over-stimulation and lead to brain fog or the inability to think clearly while the drug is still in the system. There are no studies to establish a toxicity limit for Sunifiram, but – theoretically speaking – taking too much could result in excessive activation of AMPA and NDMA receptors for glutamate. This could potentially lead to excitotoxicity from a Sunifiram overdose. Even though such cases have yet to be reported, it’s wise to proceed with caution when starting to administer any potent supplement.
As of this report, Sunifiram is regarded as being relatively safe when used within recommended dosage guidelines. There have been no cases of dangerous side effects reported by initial users and no studies have raised any cause to be concerned as of today. However, Sunifiram is still in the early stages of its history and those using these newer supplements may assume some risk when you try an emerging nootropic such as this one. The best way to address these concerns is by reading Sunifiram reviews and experience logs from other individuals to examine and research any possible side effects encountered by taking any nootropic powder.
In regards to Sunifiram, some of the more commonly reported side effects include headaches, anxiety, jitters, restlessness, insomnia, brain fog, nausea, and increased perspiration. Some experiences may not be typical and for safety’s sake, it would be best to consult a health professional before using it. You should definitely consult a doctor if you are currently taking any drugs or medications that may interfere with the effects of Sunifiram.
Since there is not much research about Sunifiram, there is not much data to report about the effects of its long-term use. Since most who have used it did so within recommended dosage guidelines, only typical short-term side effects for those who take too much have been reported. Tolerance building is a concern for any potent supplement, so it appears cycling make negate any effects of long-term use.
In regard to short-term use, it appears that as long as users administer Sunifiram according to recommended dosages rarely report any short-term negative side effects. It also appears that cycling usages of Sunifiram also help stem any tolerance building side effects.
How Long Does Sunifiram Last?
The effects of Sunifiram can last from one to three hours and is best administered at 3-5 mg three times during the day. Usage at night is not recommended as it may interrupt your sleep patterns, which can exacerbate the short-term side effects of usage.
Because it’s relatively new, there is only a fraction of medical data available for this drug in comparison to other similar nootropics. Sunifiram is a pyrrolidone derivative and is structurally related to both Unifiram (DM-232) and Sapunifiram (MN-19), as all three molecules are piperazine alkaloids. Sunifiram is a piperazine alkaloid (referring to the hexagon with two nitrogen groups) that is derived from Piracetam. Using the related structure, Unifiram as an example, the sidechain of Piracetam is fused into a piperazine structure by reconnecting it to the pyrrolidine backbone, and then Sunifiram sees an opening of the pyrrolidine backbone (not observed in Unifiram) which is known to not be vital for the cognitive enhancing properties of Piracetam-like drugs.
Sunifiram is reported to be four orders of magnitude more potent than Piracetam in regards to anti-amnesiac potential. Injections of 0.1mg/kg appear to have cognitive enhancing properties comparable to 30mg/kg Piracetam in otherwise normal adult rats. 0-100nM of Sunifiram has been noted to enhance NMDA-dependent signaling via an increase in PKCα phosphorylation, dependent on the glycine binding site and acting antagonistically to Glycine (300μM). This receptor activation activates Src, and inhibiting Src inhibits the increase in long-term potentiation. NMDA-dependent long-term potentiation has been confirmed in vivo with 0.01-1mg/kg oral intake of Sunifiram for 7-12 days.
While signaling via the NDMA receptor exhibited a bell-curve response peaking at 10nM, it was able to cause concentration-dependent enhancement of neuronal signaling up to 1,000nM due to an increase in AMPA receptor phosphorylation. Increases in AMPA receptor activation has been associated with an increase in (NMDA receptor-dependent) CAMKII phosphorylation and PKCα both of which have been confirmed in vivo with 0.01-1mg/kg Sunifiram oral ingestion and are blocked by a glycine-site NMDA antagonist. AMPA receptor activation has been noted elsewhere to be associated with the anti-amnesiac effects of Sunifiram.
In mice with hippocampal-dependent memory impairments, Sunifiram at 1mg/kg is able to abolish the reductions seen when given after training sessions. Long-term potentiation in these mice (normally impaired and also suffering memory dysfunction) was also normalized to control levels.
Is Sunifiram Legal?
Nootropics like Sunifiram are a class of supplements that are not illegal, but also unregulated by any public health agency anywhere. This means that while you can purchase it online, there is no pharmaceutical wholesaler in the U.S. that sells it. There are, however, plenty of online nootropic site that will deliver Sunifiram powder to your residence without any risk of prosecution for you or whichever organization you procure it from.
When it comes to those to take this drug, reviews by those testing it out can easily be found on sites like Reddit and other similar crowd-sharing websites. According to one Redditor discussing their first impressions, ” I ingested 6mg at 10:30 am and I took another dose of 11mg sub-lingual at 3:30 pm. I didn’t notice anything terribly remarkable, in the morning I think I experienced a mild stimulation, not unlike caffeine, perhaps a little bit cleaner, it didn’t feel like Piracetam, sensations remained the same, but I did find myself enjoying music on my headphones, I did take care of a few chores this morning and worked out, perhaps there was a little bit of drive there… I noticed a slight elevation in body temperature and was actually sweating slightly, just from the chores… the second dose I have to say I didn’t notice anything at all.” When the subject reported three days later they became “more familiar with the effects, (and) it definitely feels like a stimulant with drive and body temperature effects. It doesn’t feel like a racetam at all actually….upon reflection, Sunifiram may actually have properties, not unlike recreational stimulants, it actually reminds of other piperazines like Benzylpiperazine or Trifluoromethylphenylpiperazine… (and) has a similar feeling to the partial stimulation effects of glutaminergic recreational drugs like ketamine and the PCP analogs.”
This review backs up the experience had by many others who have tried this nootropic. Individuals who take it similarly report that it feels like a stimulant similar to using smart drugs like Adderall or Ritalin. Fortunately, Sunifiram does not come with the same negative side effects as taking an amphetamine-based ADHD drug such as the previous two mentioned above. Its also reported to dramatically increase energy levels and the ability to concentrate. Many often report using Sunifiram for motivation and to overcome procrastination both for work, school, and other similar tasks. Some have even experimented with Sunifiram as a pre-workout supplement for bodybuilding or weight loss, but these results have been found to be negligible at best and inconclusive at worst.
In the end, this nootropic seems like a more potent and more effective form of Piracetam that you must regulate the usage of with greater caution. As long as those who use Sunifiram follow recommended dosage guidelines, there is no danger of overdosing and proper cycling can prevent any potential long term risks. The benefits of this drug may vary from person to person, but those looking for a way to least improve memory and cognitive function and have experienced no benefits from similar nootropics may want to test Sunifiram for the effects they’re looking for.