The Effects Of Using Tianeptine As An Antidepressant

What Is Tianeptine?

Tianeptine is a tricyclic antidepressant which is generally used to treat a major depressive disorder, asthma, and irritable bowel syndrome. Many practitioners consider this to be one of the most effective drugs for treating mild to severe depression. Recently, its uses have increased to aiding mental clarity and increasing the feeling of well-being. Let’s take a look at the overall effects, benefits and dosage recommendations for this mood-boosting drug.


Unlike many drugs used to treat depression, Tianeptine doesn’t have mood neutralizing effects. This drug actually decreases serotonin activity levels in the brain which results in an uplifting sensation. It’s for this reason that medical practitioners feel that this is the most effective treatment for depression. The main Tianeptine antidepressant effects occur at low doses of 12-24mg 1-3 times daily.

In addition to improving moods, Tianeptine helps reduce stress, anxiety, and sorrow. So far, research has shown that there are minimal addictive and no sedative substances in this drug. Some research evidence suggests that Tianeptine can be effective for helping people deal with obsessive-compulsive disorders, social anxiety, and eating disorders. It also has the potential to lead to breakthroughs in treatment drugs for Alzheimer’s disease, aging of the brain and multiple sclerosis.

Recommended Dosage

Tianeptine pills are typically sold in 12.5-mg doses and users are recommended to take two to three pills per day. It’s important to spread the doses evenly throughout the day to give the body a consistent supply. Most medical professionals suggest that new users start with smaller doses to become familiar with the effects. Under the right conditions, the Tianeptine antidepressant effect can turn to into euphoria.

Side Effects

Tianeptine has minimal side effects. It is generally considered safe and easy to tolerate for most individuals. Mild side effects include dry mouth, constipation, dizziness, and low blood pressure. Insomnia and vivid dreams have also been associated with the use of this drug. If any of these side effects are experienced in an extreme way, contact a physician immediately. Research of limited quality has also suggested that Tianeptine may cause liver damage or cardiac arrhythmias.


Tianeptine has been included in many studies for Parkinson’s disease, post-traumatic stress disorder, and severe depression. These studies have repeatedly shown that this drug is safe and effective at treating these issues. In one study, Tianeptine was found to be more effective for treating co-existing depression and anxiety than maprotiline. Several other studies have proven that this drug is highly successful at treating panic attacks and other anxiety disorders.

Research conducted from 1998 to 2004 by various scientists has concluded that Tianeptine decreases the severity of asthma symptoms and improves lung function. A 2005 study conducted in Egypt also discovered that this drug is useful for treating depression and erectile dysfunction in men. A clinical trial performed in Spain found that it has positive effects on people with fibromyalgia as well.

Safety Concerns

Tianeptine pills are typically made with silica which doesn’t fully dissolve in the body. This material can build up in the body and cause problems. Some practitioners in Russia administer this drug intravenously. The intravenous solution is rarely filtered properly and particles can block the capillaries. This can cause thrombosis and severe necrosis. However, long-term studies conducted on rats have not found any noticeable extracellular levels of serotonin in their brains.

Legal Status

Tianeptine is approved for use in France and other European nations, as of 2016. Certain countries in Asia and Latin American have also legalized this drug. However, it is a controlled substance and requires a prescription for use. Due to the more dangerous intravenous methods used in Russia, this country has classified Tianeptine as a Schedule III controlled substance. It is not yet available in the United States, the United Kingdom, Canada, Australia or New Zealand.

Final Thoughts

Tianeptine appears to be a safe alternative to other antidepressant drugs. The side effects are minimal and the benefits cover a wide variety of disorders and diseases. However, as with all prescription drugs, it should be used under professional guidance and in conjunction with other healing methods.

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