The Recommended Dosage For Uridine Monophosphate Usage

What is the Best Uridine Monophosphate Dosage?

Often abbreviated as UMP or UDP, Uridine Monophosphate is a lesser-known nootropic that is potentially more effective than the most popular options. As a natural component of RNA, it increases the synthesis of brain phosphatidylcholine, a chemical that helps operate cells and regulate enzymes within the brain. In addition, it enhances the production of neurites in the brain which results in higher levels of synaptic plasticity and improved encoding and memory storage.

It also increases the level of dopamine, a neurotransmitter that impacts motivation and mood, in the brain. Finally, UMP assists in increasing the synthesis of Acetylcholine, a chemical involved in working memory and synaptic plasticity, in the brain. The higher the levels of UMP in the brain, the better the cognitive abilities and memory retention are.


Research indicates that Uridine Monophosphate has numerous benefits, including:

  • Boosting mood and reducing depression by increasing the levels of dopamine in the brain.
  • Enhancing motivation and improving energy levels.
  • Improves age-related memory loss and mental clarity.
  • Enhancing neurons in the brain and offering some level of protection for the brain, especially when taken with fish oil supplement.
  • Decreasing abnormal nerve firing patterns that are seen in ADD, ADHD, and seizures.

Uridine Monophosphate Dosage

Although there is no specific recommended dosage, most users find that taking one 300 mg capsule three times a day is most effective. When taken in capsule form, 150 mg to 2500 mg up to two times a day promises the best results. In addition, users tend to report that is best taken with food.

Side Effects

As a general rule, Uridine Monophosphate is a very safe nutritional supplement and users report minimal to no side effects as long as the suggested dosages above are followed. However, in some cases, users do describe mild gastrointestinal upset (diarrhea, cramping), fatigue, nervousness/ jitteriness, and headache. It is worth noting that users do report these side effects do decrease and eventually go away with continued use. Side effects of an improper Uridine Monophosphate dosage include headache, gastrointestinal issues, and a general feeling of unease. Fortunately, this only occurs if an extreme amount is taken, such as 10-15 times the recommended dose.

In addition, there is some evidence that suggests Uridine M?onophosphate supplements can lower the levels of Vitamin B12 in the body. To prevent this from happening, it is a good idea to take a B12 supplement along with the UMP or take a daily multivitamin that includes all the B-complex vitamins.

Long-Term Use

Uridine Monophosphate is completely safe for long term use and in fact, this is when it is most effective. As synapses grow and neuroplasticity improves, short term memory, recall, and recognition are greatly enhanced, while attention and concentration also see a noticeable improvement. In addition, by increasing the level of dopamine in the brain, mood and motivation are also improved. However, most users report that it takes at least two to three weeks or more to see the best results.

Short-Term Use

When used for a short period of time, Uridine Monophosphate is significantly less effective. In fact, it is important to note that you do not feel the full benefits of the supplement for several weeks after you begin taking it.


A number of studies have been completed on Uridine Monophosphate with promising results. They include:

Is Uridine Monophosphate Legal?

In the United States, it is legal to purchase and possess Uridine Monophosphate without a prescription. It may be found in retail stores, as well as online.

Online Reviews

Plenty of reviews can be found for Uridine Monophosphate left by users on a number of different sites, including Amazon. They are overwhelmingly positive with comments such as “Years worth of drug-induced brain degradation is just coming back. Never had a nootropic work this well.” Several reviewers reference its ability to make themselves and others “happier, calmer, and more focused than before.” Another reviewer stated, “It gives me a mental boost and makes it easier to ignore background distraction when trying to concentrate. Plus, I’m more balanced and motivated.”

Final Thoughts

Overall, there are a considerable number of cognitive and mood enhancement benefits associated with the use of Uridine Monophosphate supplements, while there are no real disadvantages noted. While mild side effects may occur, they are bearable and do resolve with time. If you are struggling with memory retention and recall or even depression and low energy levels, Uridine Monophosphate is definitely worth trying.

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