What Is Uridine Monophosphate Synthase?

What Is Uridine Monophosphate Synthase?

For the purposes of this article, “Uridine Monophosphate” is a really long word for a nootropic….so it will be referred to as “UMP.” I know, I know, I’m lazy af…sue me;) What is Uridine Monophosphate Synthase? For those aiming to develop their cognitive abilities and focus more on their work, UMP is a good choice. It helps them increase their productivity levels and do more with their life. So, what exactly does this drug do? Uridine Monophosphate (UMP) is a nucleotide, which, when compounded with other molecules forms RNA. Chemical preparation of this ester is done via esterification of phosphoric acid and nucleoside Uridine. In humans, this reaction is catalyzed by the Uridine Monophosphate synthase, but its deficiency can cause a metabolic disorder, namely Orotic Aciduria. However, a synthetic supplementation of UMP can help improve cognitive function and improved brain activity. Though this compound is found in the RNA of natural substances, there is no evidence for it to be delivered by any food, because of its metabolic breakdown in the liver and gastrointestinal tract.


Studies have revealed that consumption of its synthetic forms can help fix the deficiency. These compounds are generally a combination of DHA, Choline, and UMP, increasing the cognitive function. It is known to selectively increase levels of synaptic proteins and brain phosphatides. Increased synaptic activity results in a healthy function of the brain and thus improved reflexes and working efficiency. Also, this can elevate moods and append the metabolic activities. Improvement in metabolic activities results in other benefits as well. It means that the person can live a healthier life and the normal life processes are being carried out smoothly in the body.

Recommended Dosage

A recommended dosage for this complex ranges between 500-1000 mg per day. But this dosage must be diffused into smaller doses throughout a day. This Nootropic supplement is doubted to produce psychotic effects in case of extremely high dosage. Thus, doctors and consumers are advised to initiate with low doses to test its compatibility and effects. For Uridine monophosphate synthase, there is no one perfect dosage that fits all users, start with the minimal effective dosage of 500-1000mg per day, and increase as you feel is needed.

Side Effects

UMP is a Nootropic with a zero rate in adverse effects. This means that you will be able to use this drug without worry as there really isn’t something to worry about. The side effects, if any in question, are really minor ones. Some users report emotional blunting at times but that seems to be a rare symptom. Due to the high level of Dopamine secretion in the brain, it tends to cause some variation in behavioral patterns and mild discomforts, but it works perfectly otherwise. The only change is the slight change witnessed in behavioral patterns and if you’re going to use it for the shorter term, it is absolutely fine.  The only time any real side effects from Uridine Monophosphate Synthase truly occurs is if an excessive amount is taken (5-10x the recommended dose.) In the case that such should occur, benign side effects include:

  • Headache
  • Upset Stomach
  • Jitters

These side effects will not persist longer than the drug’s half-life, of about 6 hours.

Long-Term Use 

UMP is found to be a safe drug for long term medication. If used in proper procedure, besides its physiological applications, it can help support liver function. Other noted reliefs offer by this drug includes improved mood and focus. It helps users relax and feel stress-free. Uridine Monophosphate Synthase can be used long-term with no excess side effects.

Short-Term Use 

There are no side effects in short term use. In fact, the drug is beneficial and used most often for the short term due to its effects on the brain. If someone is stressed out and needs to complete a deadline, he can do it easily with UMP. In fact, UMP’s ease at helping people focus more and increasing productivity levels ensure that UMP is the right choice for people who are looking to work more. High dosing of Uridine Monophosphate Synthase (mega-dosing) is not recommended.

The Nootropic supplement brings stress relief and relaxation from fatigue. It provides improved stamina and body activity. Users feel enhanced adrenaline rush which provides them a boost of stress. Athletes use it for such boost and support. It helps in increased brain synapses and enhanced nerve cell phospholipids. It also helps enhance neurons in the brain and thus improving the focus and reflex actions.


Research reveals that when consumed orally, this drug is passed into the bloodstream in the intestines and then is released at the blood-brain barrier. Though UMP cannot pass through the gastrointestinal tract easily, in the compounded form with DHA and Choline it can pass the digestive barrier into the bloodstream and then further to the brain. This then interacts with the brain receptors causing increased synaptic response and improving brain function. Research has proven the usefulness of the drug and how it can help improve the cognitive abilities of the brain easily.

Is Uridine Monophosphate Synthase Legal?

The drugs like these help much pass through strike procedure and testing standard. They are tested under various conditions and for their effects on different cells. UMP supplement has passed through these tests with proper clearance. This is approved for human medicinal uses and is legal in many parts of the world.

Online Reviews

Reviews suggest a cautious use of the drug as it has abilities to modulate behavioral patterns, but it has advantages that are of great significance. Improving memory, helping recover bipolar disorders, enhance cholinergic brain function, all such disorders require proper care and medication, and with this supplement in the market, there is help available to counter their effects and reduce damage. But for cases, where the conditions are bit severe the drug has been observed to work inefficiently at low dosage; though it is advised to maintain a low prescribed dosage to slim chances of unknown damages. Customer reviews, as well as my personal review of Uridine Monophosphate Synthase, is that the drug is a great source of Choline, and can help make any long-term racetam use extremely worthwhile by helping to mitigate any and all side effects from high dosing of Piracetam, Aniracetam, Oxiracetam, and Pramiracetam.

Final Thoughts

It is a drug of great possibilities and application and one of the best for people looking to do more. As of yet, no side effects of this drug is known and it is fit for use by anybody. It is compounded with DHA and B-vitamins make them consumable and easily passed to the body for treatment. Since this drug has capabilities to alter dopamine levels of the system, it is advised to consume as per requirement. Based on its theoretical studies and tests, the drug is safe and can be used to treat some cognitive abnormalities. Like any neurological drug, it might have some side effects, so it is recommended to follow the directive and take care of the discomforts caused due to use to ensure successful medication. Take every bit of information you read on nootropics with a grain of salt, and be sure to do your own trials and background research before coming to a final conclusion on any nootropic drug, as each person’s biology reacts differently to different supplements.

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